Absorption of antibiotics by the bovine udder.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Ziv G; Sulman FG
  • Source:
    Journal of dairy science [J Dairy Sci] 1975 Nov; Vol. 58 (11), pp. 1637-44.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print Cited Medium: Print ISSN: 0022-0302 (Print) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE
    • Publication Information:
      Publication: Champaign, IL : American Dairy Science Association
      Original Publication: Lancaster, Pa. [etc.]
    • Subject Terms:
      Anti-Bacterial Agents/*metabolism ; Mammary Glands, Animal/*physiology; Absorption ; Animals ; Antibiotics, Antitubercular/metabolism ; Cattle ; Diffusion ; Dose-Response Relationship, Drug ; Drug Stability ; Female ; Kinetics ; Lipids ; Membranes/physiology ; Penicillins/metabolism ; Protein Binding ; Tetracyclines/metabolism
    • Abstract:
      Absorption of 39 antibiotics from the nonlactating bovine udder was compared with absorption of [carbon-14] urea as reference. First order kinetics characterized the absorption of urea and most of the antibiotics during the first 8 to 12 h after intramammary infusion. The absorption of polymyxin B, colistin, neomycin, spiramycin, and several tetracyclines was biexponential. The physicochemical properties of drugs which appeared to govern their absorption from the udder were the degree of lipid-solubility of the nonionized fraction and the dissociation constant. Antibiotic protein binding also influenced absorption. Lipid-solubility was the rate-limiting factor with drugs that are mainly dissociated in milk at pH 6.8. These compounds were absorbed at rates related to their degree of lipid-solubility of nonionized fraction. The concentration of the nonionized molecule in milk was the rate-limiting factor with drugs that were highly lipid-soluble. Results with a number of structurally-related antiobiotics, and with others of diverse structures and physical properties, added considerable confidence to the assumption that antibiotics are absorbed from the udder by nonionic (passive) diffusion. The blood-milk barrier behaves as an inert lipoid membrane to these drugs.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Antibiotics, Antitubercular)
      0 (Lipids)
      0 (Penicillins)
      0 (Tetracyclines)
    • Publication Date:
      Date Created: 19751101 Date Completed: 19760213 Latest Revision: 20031114
    • Publication Date:
      20221213
    • Accession Number:
      10.3168/jds.S0022-0302(75)84762-X
    • Accession Number:
      1194466