[Effect of magnesium stearate on the tensile strength of tablets made with the binder Prosolv SMCC 90].

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  • Author(s): Muzíková J;Muzíková J
  • Source:
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti [Ceska Slov Farm] 2002 Jan; Vol. 51 (1), pp. 41-3.
  • Publication Type:
    English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Vliv stearanu horecnatého na pevnost tablet v tahu ze suchého pojiva Prosolv SMCC 90.
    • Source:
      Publisher: Ceská lékarská spolecnost J. E. Purkyne Country of Publication: Czech Republic NLM ID: 9433765 Publication Model: Print Cited Medium: Print ISSN: 1210-7816 (Print) Linking ISSN: 12107816 NLM ISO Abbreviation: Ceska Slov Farm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceská lékarská spolecnost J. E. Purkyne,
    • Subject Terms:
      Pharmaceutic Aids* ; Tablets*; Stearic Acids/*pharmacology; Tensile Strength
    • Abstract:
      The present paper evaluated the tensile strength of tablets made from the dry binder Prosolv SMCC 90 and the influence of three concentrations of the lubricant magnesium stearate on the tensile strength of tablets manufactured from this material. The results were compared with the same evaluation in Avicel PH 102. The tested concentrations of the stearate were 0.4, 0.8 and 1.2%. The tablets were compressed by three press powers (3, 3.5, and 4 kN). On the basis of obtained results it can be stated that under the same press powers Prosolv SMCC 90 alone yields stronger compacts than Avicel PH 102. From the viewpoint of decreased strength of compacts by adding magnesium stearate, the dry binder Prosolv SMCC 90 is much less sensitive than Avicel PH 102. In Avicel PH 102 a marked decrease in tensile strength was recorded with an addition of 0.4%, which was not observed with Prosolv SMCC90. A more significant decrease in the strength of compacts was shown by the substance not until a stearate concentration of 0.8%. The highest employed stearate concentration of 1.2% decreases the tensile strength of tablets made from Prosolv SMCC 90 in the press powers of 3.5 and 4 kN two times less than the tensile strength of the compacts from Avicel PH 102.
    • Accession Number:
      0 (Pharmaceutic Aids)
      0 (Stearic Acids)
      0 (Tablets)
      4ELV7Z65AP (stearic acid)
    • Publication Date:
      Date Created: 20020326 Date Completed: 20020418 Latest Revision: 20121115
    • Publication Date:
      20231215
    • Accession Number:
      11910741