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Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro.
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- Author(s): Kalisch-Smith, J.I.; Outhwaite, J.E.; Simmons, D.G.; Pantaleon, M.; Moritz, K.M.
- Source:
Placenta; Oct2016, Vol. 46, p87-91, 5p- Subject Terms:
- Source:
- Additional Information
- Abstract: Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Placenta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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