Signals and pools underlying biphasic insulin secretion.

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  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Print ISSN: 0012-1797 (Print) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria, VA : American Diabetes Association
      Original Publication: [New York, American Diabetes Association]
    • Subject Terms:
      Calcium/*metabolism ; Insulin/*metabolism ; Islets of Langerhans/*metabolism ; Signal Transduction/*physiology; Animals ; Glucose/metabolism ; Insulin Secretion
    • Abstract:
      Rapid and sustained stimulation of beta-cells with glucose induces biphasic insulin secretion. The two phases appear to reflect a characteristic of stimulus-secretion coupling in each beta-cell rather than heterogeneity in the time-course of the response between beta-cells or islets. There is no evidence indicating that biphasic secretion can be attributed to an intrinsically biphasic metabolic signal. In contrast, the biphasic rise in cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) induced by glucose is important to shape the two phases of secretion. The first phase requires a rapid and marked elevation of [Ca(2+)](i) and corresponds to the release of insulin granules from a limited pool. The magnitude of the second phase is determined by the elevation of [Ca(2+)](i), but its development requires production of another signal. This signal corresponds to the amplifying action of glucose and may serve to replenish the pool of granules that are releasable at the prevailing [Ca(2+)](i). The species characteristics of biphasic insulin secretion and its perturbations in pathological situations are discussed.
    • Number of References:
      75
    • Accession Number:
      0 (Insulin)
      IY9XDZ35W2 (Glucose)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 20020130 Date Completed: 20030117 Latest Revision: 20220408
    • Publication Date:
      20221213
    • Accession Number:
      10.2337/diabetes.51.2007.s60
    • Accession Number:
      11815460