Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain.

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  • Author(s): Appleton DJ;Appleton DJ; Rand JS; Sunvold GD
  • Source:
    Journal of feline medicine and surgery [J Feline Med Surg] 2001 Dec; Vol. 3 (4), pp. 211-28.
  • Publication Type:
    Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Sage Country of Publication: England NLM ID: 100897329 Publication Model: Print Cited Medium: Print ISSN: 1098-612X (Print) Linking ISSN: 1098612X NLM ISO Abbreviation: J Feline Med Surg Subsets: MEDLINE
    • Publication Information:
      Publication: 2012- : London : Sage
      Original Publication: London ; Philadelphia : WB Saunders Co.,
    • Subject Terms:
      Weight Gain*; Cat Diseases/*metabolism ; Cats/*metabolism ; Diabetes Mellitus, Type 2/*veterinary ; Glucose Intolerance/*veterinary ; Insulin/*blood ; Obesity/*veterinary; Animals ; Blood Glucose/metabolism ; Cat Diseases/blood ; Cats/blood ; Diabetes Mellitus, Type 2/metabolism ; Female ; Glucose Intolerance/metabolism ; Glucose Tolerance Test/veterinary ; Insulin/metabolism ; Insulin Secretion ; Male ; Obesity/metabolism ; Time Factors
    • Abstract:
      This study quantifies the effects of marked weight gain on glucose and insulin metabolism in 16 cats which increased their weight by an average of 44.2% over 10 months. Significantly, the development of feline obesity was accompanied by a 52% decrease in tissue sensitivity to insulin and diminished glucose effectiveness. In addition, glucose intolerance and abnormal insulin response occurred in some cats. An important finding was that normal weight cats with low insulin sensitivity and glucose effectiveness were at increased risk of developing impaired glucose tolerance with obesity. High basal insulin concentrations or low acute insulin response to glucose also independently increased the risk for developing impaired glucose tolerance. Male cats gained more weight relative to females and this, combined with their tendency to lower insulin sensitivity and higher insulin concentrations, may explain why male cats are at greater risk for diabetes. Results suggest an underlying predisposition for glucose intolerance in some cats, which is exacerbated by obesity. These cats may be more at risk of progressing to overt type 2 diabetes mellitus.
      (Copyright 2001 European Society of Feline Medicine.)
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    • Accession Number:
      0 (Blood Glucose)
      0 (Insulin)
    • Publication Date:
      Date Created: 20020214 Date Completed: 20020221 Latest Revision: 20240821
    • Publication Date:
      20240821
    • Accession Number:
      PMC10822293
    • Accession Number:
      10.1053/jfms.2001.0138
    • Accession Number:
      11795959