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Lentiviral vectors, two decades later.
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- Abstract:
The article discusses the use of lentiviruses as a gene delivery tool in gene therapy. Topics include a 1994 experiment in which HIV-derived vectors were used to transduce neurons in rat brains, the deletion of promoter-enhancer sequences in the long terminal repeats (LTRs) of the integrated transgenes through elf-inactivating design to minimize the pathogenic features of the parent virus used, and the application of lentiviral vectors in cancer immunotherapy.
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