Prevention of spinal cord injury with time-frequency analysis of evoked potentials: an experimental study.

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  • Author(s): Hu Y;Hu Y; Luk KD; Lu WW; Holmes A; Leong JC
  • Source:
    Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2001 Dec; Vol. 71 (6), pp. 732-40.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Validation Study
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print Cited Medium: Print ISSN: 0022-3050 (Print) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE
    • Publication Information:
      Publication: London : BMJ Publishing Group
      Original Publication: London : British Medical Association
    • Subject Terms:
      Disease Models, Animal* ; Evoked Potentials, Motor* ; Evoked Potentials, Somatosensory* ; Fourier Analysis* ; Signal Processing, Computer-Assisted*; Monitoring, Intraoperative/*methods ; Spinal Cord Injuries/*diagnosis ; Spinal Cord Injuries/*prevention & control; Algorithms ; Analysis of Variance ; Animals ; Cerebral Cortex/physiopathology ; Monitoring, Intraoperative/standards ; Rats ; Reaction Time ; Sensitivity and Specificity ; Spinal Cord/physiopathology ; Spinal Cord Injuries/etiology ; Spinal Cord Injuries/physiopathology ; Time Factors
    • Abstract:
      Objectives: To verify the applicability and validity of time-frequency analysis (TFA) of evoked potential (EP) signals in detecting the integrity of spinal cord function and preventing spinal cord injury.
      Methods: The spinal cord was simulated during surgery in 20 mature rats by mechanically damaging the spinal cord. Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), cortical motor evoked potential (CMEP), and spinal cord evoked potential (SCEP) were used to monitor spinal cord function. Short time Fourier transform (STFT) was applied to the CSEP signal, and cone shaped distribution (CSD) was used as the TFA algorithm for SSEP, CMEP, and SCEP signals. The changes in the latency and amplitude of EP signals were measured in the time domain, and peak time, peak frequency, and peak power were measured in the time-frequency distribution (TFD).
      Results: The TFDs of EPs were found to concentrate in a certain location under normal conditions. When injury occurred, the energy decreased in peak power, and there was a greater dispersion of energy across the time-frequency range. Strong relations were found between latency and peak time, and amplitude and peak power. However, the change in peak power after injury was significantly larger than the corresponding change in amplitude (p<0.001 by ANOVA).
      Conclusions: It was found that TFA of EPs provided an earlier and more sensitive indication of injury than time domain monitoring alone. It is suggested that TFA of EP signals should therefore be useful in preventing spinal cord injury during surgery.
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    • Publication Date:
      Date Created: 20011128 Date Completed: 20011228 Latest Revision: 20191210
    • Publication Date:
      20240829
    • Accession Number:
      PMC1737639
    • Accession Number:
      10.1136/jnnp.71.6.732
    • Accession Number:
      11723192