Nontraditional aspects of aldosterone physiology.

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  • Author(s): Ngarmukos C;Ngarmukos C; Grekin RJ
  • Source:
    American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2001 Dec; Vol. 281 (6), pp. E1122-7.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print Cited Medium: Print ISSN: 0193-1849 (Print) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bethesda, MD. : American Physiological Society
    • Subject Terms:
      Cardiovascular Physiological Phenomena*; Aldosterone/*physiology; Aldosterone/biosynthesis ; Aldosterone/genetics ; Humans ; Receptors, Mineralocorticoid/genetics ; Receptors, Mineralocorticoid/physiology
    • Abstract:
      Aldosterone is the most important circulating mineralocorticoid. It is secreted by the zona glomerulosa of the adrenal gland and plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct, promoting sodium resorption and potassium excretion. The action of aldosterone on its classic target epithelia has been extensively studied, and many of the signaling events that mediate its effects have been described. Recently, there has been increased interest in aldosterone actions on the cardiovascular system, which are mediated through nonclassical actions. These include local tissue production, nongenomic actions, and effects on nonepithelial targets. In this review article, we focus on the effects of aldosterone in nonepithelial tissues that are mediated through MR, especially cardiovascular effects.
    • Number of References:
      69
    • Accession Number:
      0 (Receptors, Mineralocorticoid)
      4964P6T9RB (Aldosterone)
    • Publication Date:
      Date Created: 20011110 Date Completed: 20020103 Latest Revision: 20171213
    • Publication Date:
      20231215
    • Accession Number:
      10.1152/ajpendo.2001.281.6.E1122
    • Accession Number:
      11701424