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Erythropoietin--a novel concept for neuroprotection.
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- Author(s): Sirén AL;Sirén AL; Ehrenreich H
- Source:
European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2001 Aug; Vol. 251 (4), pp. 179-84.
- Publication Type:
Journal Article; Review
- Language:
English
- Additional Information
- Source:
Publisher: Springer International Country of Publication: Germany NLM ID: 9103030 Publication Model: Print Cited Medium: Print ISSN: 0940-1334 (Print) Linking ISSN: 09401334 NLM ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Subsets: MEDLINE
- Publication Information:
Original Publication: Berlin ; New York : Springer International, c1990-
- Subject Terms:
- Abstract:
Neuroprotection as a means to prevent or oppose pathological neuronal loss in central nervous system disease of various pathophysiological origins represents a novel therapeutic approach. This approach is supported by extensive experimental evidence on cell culture and animal studies demonstrating beneficial effects of growth factors on neuronal survival and functional recovery. The clinical use of neuroprotective agents has been hampered by the toxicity of many of the compounds that showed promising therapeutic potential in animal studies. The focus of this review is on a novel neuroprotective approach with erythropoietin, a hematopoietic growth factor that: 1) is expressed in the human central nervous system, 2) is hypoxia-inducible, 3) has demonstrated remarkable neuroprotective potential in cell culture and animal models of disease, 4) has multiple protective effects (antiapoptotic, neurotrophic, antioxidant, angiogenic), and 5) is a clinically extremely well tolerated compound.
- Number of References:
42
- Accession Number:
0 (DNA-Binding Proteins)
0 (HIF1A protein, human)
0 (Hypoxia-Inducible Factor 1)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (Neuroprotective Agents)
0 (Nuclear Proteins)
0 (Receptors, Erythropoietin)
0 (Recombinant Proteins)
0 (Transcription Factors)
11096-26-7 (Erythropoietin)
- Publication Date:
Date Created: 20011108 Date Completed: 20020206 Latest Revision: 20220317
- Publication Date:
20250114
- Accession Number:
10.1007/s004060170038
- Accession Number:
11697582
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