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Association of Motoric Cognitive Risk Syndrome With Brain Volumes: Results From the GAIT Study.
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- Author(s): Beauchet, Olivier; Allali, Gilles; Annweiler, Cédric; Verghese, Joe
- Source:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Aug2016, Vol. 71 Issue 8, p1081-1088, 8p, 3 Charts- Subject Terms:
GAIT disorders; MAGNETIC resonance imaging; PSYCHIATRIC drugs; COGNITION disorders; MOTOR ability; PSYCHOLOGY; PHYSIOLOGY; ACADEMIC medical centers; BRAIN; COMPARATIVE studies; DEMENTIA; GAIT in humans; NEUROPSYCHOLOGICAL tests; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SYNDROMES; EVALUATION research; INDEPENDENT living; DISEASE incidence; DISEASE prevalence; CROSS-sectional method; GRAY matter (Nerve tissue) - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: The "motoric cognitive risk" (MCR) syndrome is a newly reported predementia syndrome combining cognitive complaint and slow gait speed. We hypothesized that individuals with MCR syndrome would have lower brain volumes compared with non-MCR individuals. This study aims (i) to compare the cognitive profile of nondemented older community-dwellers with and without MCR syndrome and (ii) to examine association of global and regional brain volumes with MCR syndrome.Methods: A total of 171 individuals (28 MCR and 143 non-MCR) were included in this cross-sectional study. Total white matter abnormalities, total white matter, total cortical and subcortical gray matters, hippocampus, motor cortex, premotor cortex, and prefrontal cortex were examined. Brain volumes were quantified from a three-dimensional T1-weighted magnetic resonance imaging using semi-automated software. Age, gender, education level, number of drugs taken daily, use of psychoactive drugs, and cognitive profile were also measured.Results: The distribution of cognitively healthy individuals and those with mild cognitive impairment was not different in participants with and without MCR. Multiple logistic regression models showed that smaller volumes of total gray matter (p = .016), total cortical gray matter (p = .010), premotor cortex (p = .018), prefrontal cortex (p = .026), and dorsolateral segment of prefrontal cortex (p = .032) were associated with MCR status. The premotor cortex presented the highest mean difference for brain regional volume between MCR and non-MCR participants (p = .03).Conclusions: The findings revealed similar cognitive profile in MCR and non-MCR participants, and MCR-related smaller global and regional gray matter volumes involving premotor and prefrontal cortices, suggesting that the MCR syndrome may predict cortical neurodegenerative dementia more than subcortical dementia. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journals of Gerontology Series A: Biological Sciences & Medical Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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