Effects of Anti- CD45 RB Monoclonal Antibody for T Lymphocyte Subsets in Mice Heart Transplantation Model.

MONOCLONAL antibodies; HEART transplantation; CD45 antigen; T cells; CELL proliferation; IMMUNOLOGICAL tolerance; LABORATORY mice

Anti- CD45 RB monoclonal antibody (anti- CD45 RBmAb), as a new immune tolerance inducer, may inhibit T cell proliferation and induce immune tolerance through competitive combination with CD45 RB on the T cell surface, which blocks the conduction of activation signals. However, how anti- CD45 RBmAb plays its role on T lymphocyte subsets during immunosuppression remains unclear. In this work, we investigate the effects of anti- CD45 RBmAb on CD3+ T lymphocyte both in vitro and in allogeneic heart transplant model in vivo. Interestingly, anti- CD45 RBmAb could inhibit the proliferation of T cells, promote the transformation of T lymphocyte to Treg and Th2 cells, suppress the transformation to Th17 and Th1 cells, increase the number of Ts cells, decrease the number of Tm cells and thus play a role in immune inhibition and induction of immune tolerance. [ABSTRACT FROM AUTHOR]