Human physiologic factors in respiratory uptake of 1,3-butadiene.

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  • Author(s): Lin YS;Lin YS; Smith TJ; Kelsey KT; Wypij D
  • Source:
    Environmental health perspectives [Environ Health Perspect] 2001 Sep; Vol. 109 (9), pp. 921-6.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Environmental Exposure* ; Respiration*; Butadienes/*pharmacokinetics ; Mutagens/*pharmacokinetics; Adult ; Body Weight ; Butadienes/adverse effects ; Female ; Humans ; Inhalation Exposure ; Lung/chemistry ; Male ; Mutagens/adverse effects ; Reference Values ; Regression Analysis ; Smoking
    • Abstract:
      1,3-Butadiene (BD), a suspected human carcinogen, is used as the raw material in industries to make synthetic butyl rubber and plastics. Simulation models using experimental animal data have shown that physiologic factors play an important role in the kinetic behavior of BD. However, human data are limited. The aim of this inhalation study was to identify influential human physiologic factors in the respiratory uptake of BD. We recruited 133 healthy volunteers in Boston, Massachusetts, into this study and tested them under an approved human subjects protocol. Each subject was exposed to 2 ppm (4.42 mg/m3) BD for 20 min, followed by purified air for another 40 min. Five exhaled breath samples collected during exposure were used to determine the respiratory uptake of BD, which was defined as absorbed BD (micrograms) per kilogram of body weight during exposure. Although subjects were given identical administered doses (40 ppm x min), there was a wide range of uptake, 0.6-4.9 microg/kg. Of the studied physiologic factors, the blood:air partition coefficient and alveolar ventilation were most significant in determining the respiratory uptake (p < 0.001 for each). In addition, in the multiple regression analysis, females had significantly higher respiratory uptake of BD than males on a weight basis. For all subjects, increasing age and cigarette smoking led to significantly decreased respiratory uptake of BD. The results of this human study are consistent with previous kinetic simulations and animal studies. The findings also suggest that interindividual variation in human physiologic factors that affect the exposure-internal dose relationship should be considered while also exploring exposure-disease associations in future epidemiologic research.
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    • Grant Information:
      07586 United States PHS HHS; ES00002 United States ES NIEHS NIH HHS
    • Accession Number:
      0 (Butadienes)
      0 (Mutagens)
      JSD5FGP5VD (1,3-butadiene)
    • Publication Date:
      Date Created: 20011024 Date Completed: 20011204 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC1240442
    • Accession Number:
      10.1289/ehp.01109921
    • Accession Number:
      11673121