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Unhappy neighbourhood: spatial genome organisation and lymphomagenesis in B cells.
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- Abstract:
Presents a commentary regarding the spatial organization of genomes, and the development of human B-cell lymphomas. Characterization of B-cell lymphomas by chromosomal translocations involving immunoglobulin genes, and different oncogene loci; Observation that Ig-gene remodelling processes can pre-dispose the Ig gene for recombination; Importance of physical proximity in the translocation process; Analysis of research conducted by Jeffrey Roix and colleagues.
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