Lysosomal and lipid alterations in the digestive gland of mussels, Mytilus galloprovincialis (L.) as biomarkers of environmental stress.

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  • Author(s): Domouhtsidou GP;Domouhtsidou GP; Dimitriadis VK
  • Source:
    Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2001; Vol. 115 (1), pp. 123-37.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print Cited Medium: Print ISSN: 0269-7491 (Print) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
    • Publication Information:
      Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
    • Subject Terms:
      Environmental Exposure*; Biomarkers/*analysis ; Bivalvia/*physiology ; Lipids/*chemistry ; Lysosomes/*chemistry; Animals ; Digestive System ; Environmental Monitoring ; Lipids/analysis ; Resins, Plant
    • Abstract:
      Lysosomal and lipid alterations in the digestive gland cells of the common mussel Mytilus galloprovincialis collected from six stations along Thermaikos Gulf (Northern Greece) were monitored through a 1-year period. The ultrastructural observations of the digestive cells of sampled mussels indicated a higher incidence of "granular" or "dark" residual bodies in the relatively more polluted stations compared to less polluted ones. Alterations in the lysosomal system of digestive cells were assessed: (1) using the lysosomal membrane stability test (2) quantifying lysosomal structural alterations of the residual bodies and the heterolysosomes of the digestive cells at the ultrastructural level, and (3) determining the elemental composition of lysosomes by means of X-ray microanalysis on epoxy resin sections. Evaluation of neutral lipids was realized using image analysis on histochemical resin sections. Mussels from the most heavily polluted stations exhibited reduced lysosomal membrane stability, higher volume density and diameter of heterolysosomes and residual bodies, and, in some cases, relatively higher lysosomal heavy metal content compared to mussels from less polluted stations. The results showed that the lysosomal membrane stability and the volume density of the residual bodies are more sensitive to general stress compared to the other biomarkers used, and could be used successfully as early warning tools in biomonitoring programs.
    • Accession Number:
      0 (Biomarkers)
      0 (Lipids)
      0 (Resins, Plant)
    • Publication Date:
      Date Created: 20011006 Date Completed: 20020129 Latest Revision: 20190901
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0269-7491(00)00233-5
    • Accession Number:
      11586767