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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edisto Island Library
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
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Closed for renovations
Phone: (843) 883-3914
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Phone: (843) 805-6909
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بررسی ارتباط خونریزي سیستم اعصاب مرکزي در کمبود فاکتور 13 با پلی مورفیسم در ژن مهارکننده فیبرینولیز فعال شونده توسط ترومبین (Persian)
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- Author(s): نادري, مجید; درگلاله, اکبر; علیزاده, شعبان; کاظمی, احمد; درگاهی, حسین; طبیبیان, شادي; یونسی, محمدرضا; خطیب, زهرا کاشانی
- Source:
Arak Medical University Journal; 2013, Vol. 16 Issue 7, p83-90, 8p- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Assessment of relationship between central nervous system bleeding in factor XIII deficiency and Thrombin-Activatable Fibrinolysis Inhibitor polymorphism. (English)
- Abstract: Background: Central nervous system bleeding is a common but life threatening complication in patients with factor XIII deficiency. The aim of this study was to assess the relationship between central nervous system bleeding with a common polymorphism of thrombin activatable fibrinolysis inhibitor (TAFI). Material and Methods: This case control study was performed on 34 patients with factor XIII deficiency and history of CNS bleeding and 36 patients with factor XIII deficiency without CNS bleeding as control group. Initially all patients were molecularly analyzed for factor XIII deficiency, then both groups were assessed for TAFI Thr325Ile polymorphism. Finally obtained data was analyzed by independent t-test. Results: Molecular analysis of TAFI Thr325Ile polymorphism revealed that 89% of patients with CNS bleeding had this mutation and 67% of patients were homozygote. There is a significant relationship between Thr325Ile polymorphism in homozygote manner with incidence of CNS bleeding in factor XIII deficient (OR 18/9, 95% CI 3/8 to 95/1). Conclusion: It seems that Thr325Ile polymorphism is an important prognostic factor of CNS bleeding in patients with factor XIII deficiency and increases the risk of CNS bleeding by 20 fold. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Arak Medical University Journal is the property of Arak University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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