Animal Models Are Valid to Uncover Disease Mechanisms.

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    • Abstract:
      The article discusses the importance of animal models for research aimed at uncovering the mechanism of autism spectrum disorder (ASD). Topics discussed include the association of copy number variations (CNV) with ASD and the metabolic discrepancy concerning the metabolic defects between mice and humans carrying the 16p11.2 BP4-BP5 rearrangements. Also noted is the importance of genetic background for detecting behavioral ASD-related phenotypes.