[Teratogenicity study of 2,2,3,3,3-pentafluoro-1-propanol (5FP) in rats by oral administration].

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  • Author(s): Usami M;Usami M; Sakemi K; Kurebayashi H; Ohno Y
  • Source:
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences [Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku] 2000 (118), pp. 45-9.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo, Kagaku Busshitsu Jōhōbu Country of Publication: Japan NLM ID: 9807834 Publication Model: Print Cited Medium: Print ISSN: 1343-4292 (Print) Linking ISSN: 13434292 NLM ISO Abbreviation: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tōkyō : Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo, Kagaku Busshitsu Jōhōbu, Heisei 9-nen [1997]-
    • Subject Terms:
      Detergents/*toxicity ; Fluorocarbons/*toxicity ; Propanols/*toxicity; Abnormalities, Drug-Induced ; Administration, Oral ; Animals ; Body Weight/drug effects ; Detergents/administration & dosage ; Eating/drug effects ; Female ; Fetus/drug effects ; Fluorocarbons/administration & dosage ; Male ; Maternal-Fetal Exchange ; No-Observed-Adverse-Effect Level ; Pregnancy ; Propanols/administration & dosage ; Rats ; Rats, Wistar
    • Abstract:
      Teratogenicity of 2,2,3,3,3-pentafluoro-1-propanol (5FP), an alternative cleaning agent for chlorofluorocarbon, was examined in rats. 5FP was diluted with sesame oil and given to pregnant rats (Crj: Wistar) by gavage once a day from day 7 to 17 of pregnancy at doses of 0, 250, 500 and 1000 mg/kg/day. The pregnant rats were sacrificed on day 20 of pregnancy and their fetuses were examined for malformation. In the pregnant rats, 5FP caused wheezing, salivation, ptosis, reduced body weight gain and reduced food consumption at 500 and 1000 mg/kg/day. In the fetuses, 5FP reduced body weight, increased the incidences of skeletal variations and retarded the ossification at 1000 mg/kg/day, but did not increase the incidences of malformations. It was concluded from these results that 5FP has no teratogenicity in rats when given by gavage. The no-observed-adverse-effect level was 500 mg/kg/day for rat fetuses, and 250 mg/kg/day for pregnant rats.
    • Accession Number:
      0 (2,2,3,3,3-pentafluoro-1-propanol)
      0 (Detergents)
      0 (Fluorocarbons)
      0 (Propanols)
    • Publication Date:
      Date Created: 20010906 Date Completed: 20011204 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      11534126