A comparative study of the allergenicity of quaternary ammonium compounds in guinea-pigs.

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    • Subject Terms:
      AMMONIUM compounds; ALLERGENS; CONTACT dermatitis; GUINEA pigs; DELAYED hypersensitivity; CAVIIDAE
    • Abstract:
      A series of eight structurally-related quaternary ammonium compounds (quats--the numbers for quats are synonymous with Colipa numbers) and one preservative formula which equilibrates to produce two other quaternary ammonium salts (Kathon CG[SUP4]), were tested for their ability to induce allergic contact hypersensitivity in guinea-pigs. A modified Freunds Complete Adjuvant Test (FCAT) was used, together with the guineapig Maximization Test (GPMT), on to and 20 animals, respectively. Of the nine substances tested by these methods, two were designated as strong allergens, whereas Kathon CG could function as a strong allergen at concentrations high enough to provide the quaternary ammonium ion in the equilibrium mixture. Evidence will be presented to support the hypothesis that only those quats which arc capable of forming stable "inn-pairs" with epidermal sites can provide immunogenic complexes which elicit the immune response. [ABSTRACT FROM AUTHOR]
    • Abstract:
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