The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and secreted (RANTES) in the relationship between air pollution and asthma among children.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Ando M;Ando M; Shima M; Adachi M; Tsunetoshi Y
  • Source:
    Archives of environmental health [Arch Environ Health] 2001 May-Jun; Vol. 56 (3), pp. 227-33.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Heldref Publications Country of Publication: United States NLM ID: 0212627 Publication Model: Print Cited Medium: Print ISSN: 0003-9896 (Print) Linking ISSN: 00039896 NLM ISO Abbreviation: Arch Environ Health Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : Heldref Publications
      Original Publication: Chicago, American Medical Assn.
    • Subject Terms:
      Air Pollution/*adverse effects ; Asthma/*epidemiology ; Asthma/*etiology ; Chemokine CCL5/*blood ; Immunoglobulin E/*blood ; Intercellular Adhesion Molecule-1/*blood ; Vascular Cell Adhesion Molecule-1/*blood; Air Pollutants/analysis ; Asthma/blood ; Asthma/immunology ; Case-Control Studies ; Child ; Female ; Humans ; Japan/epidemiology ; Male ; Nitrogen Dioxide/analysis ; Particle Size
    • Abstract:
      To evaluate the role of adhesion molecules and chemokines in the relationship between air pollution and asthma, the authors determined the following in 230 children who lived in 4 communities in Japan that had different levels of air pollution: serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1); soluble vascular cell adhesion molecule-1 (sVCAM-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and total immunoglobulin E (IgE). Children with asthma or who exhibited wheezing (n = 115) and nonasthmatic children (n = 115) were studied. Serum concentrations of sICAM-1, sVCAM-1, and RANTES were increased significantly in asthmatic children, compared with nonasthmatic children. Nonasthmatic children with serum IgE levels that were greater than or equal to 250 IU/ml had significantly lower concentrations of sICAM-1 and sVCAM-1 than the other children. The geometric means of sICAM-1 increased as air pollution increased. The results of this study suggest that adhesion molecules or chemokines are associated with asthma and that ICAM-1 may play an important role in the relationship between air pollution and the occurrence of asthma.
    • Accession Number:
      0 (Air Pollutants)
      0 (Chemokine CCL5)
      0 (Vascular Cell Adhesion Molecule-1)
      126547-89-5 (Intercellular Adhesion Molecule-1)
      37341-29-0 (Immunoglobulin E)
      S7G510RUBH (Nitrogen Dioxide)
    • Publication Date:
      Date Created: 20010802 Date Completed: 20010809 Latest Revision: 20161219
    • Publication Date:
      20221213
    • Accession Number:
      10.1080/00039890109604446
    • Accession Number:
      11480498