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Inhibitory effect of somatostatin on neutral amino acid transport in isolated brain microvessels.
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- Additional Information
- Source:
Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Print ISSN: 0022-3042 (Print) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE
- Publication Information:
Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry
Original Publication: New York : Raven Press
- Subject Terms:
- Abstract:
In the presence of somatostatin-14 or some of its receptorial agonists, the uptake of large neutral amino acids by isolated brain microvessels was found to be inhibited up to 50%, no other transport system being affected. Although the luminal and abluminal sides of brain endothelial cells are both capable of taking up large neutral amino acids, only uptake from the abluminal side appears to be inhibited by somatostatin. The involvement of a type-2 somatostatin receptor was suggested by assays with a series of receptor-specific somatostatin agonists, and was confirmed by the release of inhibition caused by a specific type-2 receptor antagonist. A type-2-specific mRNA was indeed shown to be present in both bovine brain microvessels ex vivo and primary cultures of endothelial cells from rat brain microvessels.
- Accession Number:
0 (Amino Acids, Neutral)
0 (RNA, Messenger)
0 (Receptors, Somatostatin)
51110-01-1 (Somatostatin)
D73QL0OMU2 (somatostatin receptor 2)
RWM8CCW8GP (Octreotide)
- Publication Date:
Date Created: 20010720 Date Completed: 20010823 Latest Revision: 20190630
- Publication Date:
20240829
- Accession Number:
10.1046/j.1471-4159.2001.00412.x
- Accession Number:
11461970
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