Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia.

THERAPEUTIC use of monoclonal antibodies; SYMPTOMS; BIOTHERAPY; ONCOLOGY nursing; CENTRAL nervous system; LYMPHOBLASTIC leukemia; MONOCLONAL antibodies; NURSES; NURSING assessment; DISEASE relapse; OCCUPATIONAL roles; TREATMENT effectiveness; DISEASE remission; PREVENTION

Background: Patients with acute lymphocytic leukemia (ALL) often experience relapse of their disease following standard treatment. Blinatumomab (Blincyto®) is a newly approved option for inducing remission in individuals with relapsed or refractory Philadelphia chromosome-negative B-cell ALL. Objectives: This article provides an overview of blinatumomab, its benefits demonstrated in clinical trials, adverse effects, administration details, and the role of the oncology nurse in caring for and educating patients who receive blinatumomab. Methods: This article summarizes the results of two phase II studies on blinatumomab and provides practice implications for nurses caring for patients receiving this therapy. Findings: Attentive symptom monitoring and management are crucial. Individuals who achieve remission from blinatumomab can then be considered for stem cell transplantation and a chance for cure. [ABSTRACT FROM AUTHOR]