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Virgin olive oil rich in phenolic compounds modulates the expression of atherosclerosis-related genes in vascular endothelium.
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- Author(s): Meza-Miranda, Eliana; Rangel-Zúñiga, Oriol; Marín, Carmen; Pérez-Martínez, Pablo; Delgado-Lista, Javier; Haro, Carmen; Peña-Orihuela, Patricia; Jiménez-Morales, Ana; Malagón, María; Tinahones, Francisco; López-Miranda, José; Pérez-Jiménez, Francisco; Camargo, Antonio
- Source:
European Journal of Nutrition. Mar2016, Vol. 55 Issue 2, p519-527. 9p. 1 Diagram, 3 Graphs. - Source:
- Additional Information
- Subject Terms: ATHEROSCLEROSIS prevention; BLOOD-vessel physiology; ENDOTHELIUM physiology; INFLAMMATION prevention; GENES; ANTIOXIDANTS; BIOLOGICAL models; COMPARATIVE studies; CROSSOVER trials; FASTING; INGESTION; OLIVE oil; PHENOLS; POLYMERASE chain reaction; PROBABILITY theory; RESEARCH funding; STATISTICAL sampling; STATISTICS; DATA analysis; OXIDATIVE stress; METABOLIC syndrome; RANDOMIZED controlled trials; BLIND experiment; DATA analysis software; DESCRIPTIVE statistics; IN vitro studies; ONE-way analysis of variance
- Subject Terms:
- Abstract: Purpose: Previous studies have shown the anti-inflammatory and antioxidant properties of phenolic compounds of virgin olive oil (VOO). However, the effect of bioavailable phenolic compounds on the vascular endothelium is unknown. We aimed to evaluate the effect of the consumption of virgin olive oil rich in phenolic compounds on the vascular endothelium. Methods: We treated HUVEC with human serum obtained in fasting state and after the intake of a breakfast prepared with VOO with a high or low content of phenolic compounds. Results: Treatment of HUVEC with serum obtained 2 h after the intake of the high-phenol VOO-based breakfast decreased p65 and MCP- 1 gene expression ( p < 0.001 and p = 0.002, respectively) and increased MT- CYB, SDHA and SOD1 gene expression ( p = 0.004, p = 0.012 and p = 0.001, respectively), as compared with the treatment of HUVEC with the serum obtained 2 h after the intake of the low-phenol VOO-based breakfast. The treatment with serum obtained 4 h after the intake of the high-phenol VOO-based breakfast decreased MCP- 1 and CAT gene expression ( p < 0.001 and p = 0.003, respectively) and increased MT- CYB gene expression ( p < 0.001), as compared to the treatment with serum obtained 4 h after the intake of the low-phenol VOO-based breakfast. Conclusion: Our results suggest that the consumption of virgin olive oil rich in phenolic compounds may reduce the risk of atherosclerosis development by decreasing inflammation and improving the antioxidant profile in the vascular endothelium. [ABSTRACT FROM AUTHOR]
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