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Wando Mount Pleasant Library
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Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1.
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- Author(s): Procario, Megan C.1; McCarthy, Mary K.2; Levine, Rachael E.1; Molloy, Caitlyn T.1; Weinberg, Jason B.1,2
- Source:
Virus Research. Mar2016, Vol. 214, p26-32. 7p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Neonatal mice are more susceptible than adults to mouse adenovirus type 1 (MAV1) respiratory infection. In adult mice, MAV-1 respiratory infection induces production of prostaglandin E 2 (PGE 2 ), a lipid mediator that exerts suppressive effects on a variety of host immune functions. We tested the hypothesis that exaggerated PGE 2 production in neonatal mice contributes to increased susceptibility to MAV-1. PGE 2 concentrations were lower in lungs of uninfected neonatal mice than in adults. PGE 2 production was induced by both MAV-1 and a nonspecific stimulus to a greater degree in neonatal mice than in adults, but only in adults was PGE 2 induced in a virus-specific manner. Lung viral loads were equivalent in PGE 2 -deficient neonatal mice and wild type controls, as was virus-induced expression of IFN-γ, IL-17A, and CCL5 in the lungs. PGE 2 deficiency had minimal effect on production of virus-specific IgG or establishment of protective immunity in neonatal mice. Collectively, our data indicate that lung PGE 2 production is exaggerated early in life, but this effect does not mediate increased susceptibility to MAV-1 infection. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Virus Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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