Hypertonic glucose preloads act preabsorptively to decrease intake in rats on postnatal day 18.

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  • Author(s): Weller A;Weller A; Tsitolovskya L; Smith GP
  • Source:
    Physiology & behavior [Physiol Behav] 2001 Jan; Vol. 72 (1-2), pp. 199-203.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print Cited Medium: Print ISSN: 0031-9384 (Print) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
    • Publication Information:
      Publication: New York NY : Elsevier Science
      Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
    • Subject Terms:
      Eating/*drug effects ; Glucose Solution, Hypertonic/*pharmacology; Animals ; Antimetabolites/pharmacology ; Deoxyglucose/pharmacology ; Dose-Response Relationship, Drug ; Female ; Glucose Solution, Hypertonic/administration & dosage ; Injections, Intraperitoneal ; Male ; Rats ; Rats, Sprague-Dawley ; Satiety Response/drug effects
    • Abstract:
      To determine if preloads of glucose act preabsorptively or postabsorptively to inhibit intake, 18-day-old rat pups were deprived for 24 h and then provided with sweet milk during a 30-min independent ingestion test. Five minutes before the test, gastric preloads (5% body weight, BW) or intraperitoneal injections (4 ml/kg BW) of isotonic, hypotonic, and hypertonic solutions of glucose or 2-deoxy-D-glucose (2-DG) were administered. There were two major results: First, preloads of 20% glucose decreased intake much more than intraperitoneal injections of 20% glucose. Second, a preload of 20% 2-DG, which decreases, rather than increases glucose utilization, was as effective as a preload of 20% glucose in decreasing intake. These results are consistent with a preabsorptive osmotic mechanism, but not with a postabsorptive metabolic mechanism, for mediating most, if not all, of the inhibition of intake 5 min after preloads of 20% glucose in rats on postnatal day 18 (P18).
    • Grant Information:
      MH40010 United States MH NIMH NIH HHS
    • Accession Number:
      0 (Antimetabolites)
      0 (Glucose Solution, Hypertonic)
      9G2MP84A8W (Deoxyglucose)
    • Publication Date:
      Date Created: 20010310 Date Completed: 20010510 Latest Revision: 20190712
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/s0031-9384(00)00391-7
    • Accession Number:
      11239998