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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Otranto Road Library
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John's Island Library
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Hurd/St. Andrews Library
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Diagnostic delay and prognosis in primary central nervous system lymphoma compared with glioblastoma multiforme.
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- Author(s): Cerqua, R.; Balestrini, S.; Perozzi, C.; Cameriere, V.; Renzi, S.; Lagalla, G.; Mancini, G.; Montanari, M.; Leoni, P.; Scerrati, M.; Iacoangeli, M.; Silvestrini, M.; Luzzi, S.; Provinciali, L.
- Source:
Neurological Sciences. Jan2016, Vol. 37 Issue 1, p23-29. 7p. 3 Charts, 1 Graph. - Source:
- Additional Information
- Subject Terms: LYMPHOMAS; GLIOBLASTOMA multiforme; CENTRAL nervous system diseases; COMPARATIVE studies; BRAIN imaging; BIOPSY; DIAGNOSIS; PROGNOSIS; LYMPHOMA diagnosis; AGE factors in disease; BONE marrow; CENTRAL nervous system tumors; COMPUTED tomography; GLIOMAS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; MEDICAL errors; MULTIVARIATE analysis; RESEARCH; TIME; EVALUATION research; RETROSPECTIVE studies; SEVERITY of illness index; KAPLAN-Meier estimator
- Abstract: Glioblastoma multiforme (GBM) and primary central nervous system lymphoma (PCNSL) are malignant cerebral neoplasms associated with poor prognosis. Early diagnosis and subsequent planning of adequate treatment strategy are relevant to improve survival and reduce neurological deficit. Two groups of patients affected by GBM and PCNSL were compared to identify: (1) factors influencing the time necessary to obtain a correct diagnosis; (2) the influence of the interval time from clinical onset to diagnosis on the prognosis. Fifty-six patients (28 PCNSL and 28 GBM, 23 females and 33 males) referred to the same hospital setting were retrospectively evaluated. The mean age at diagnosis was 61 years. The two groups were comparable in terms of age, sex, clinical symptoms at onset and performance status. There was no relevant difference in time span from clinical onset to first neuroimaging examination, while time span from first neuroimaging to final morphological diagnosis was much longer in PCNSL patients (p = 0.008). Multivariate Cox regression analysis, including both PCNSL and GBM cases, showed a significant association of the overall survival with: time to diagnosis (HR 0.06), age at onset (HR 1.04). Our results show a significant diagnostic delay in PCNSL cases. Age at onset of disease and time to diagnosis emerge as clinical factors affecting overall survival in both groups. Stereotactic-guided biopsy should be chosen as routine method to early diagnose PCNSL. The clinical relevance of early diagnosis in GBM and PCNSL needs to be emphasized to maximize the overall survival in both neoplasms. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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