Neurophysiological studies in acute transverse myelitis.

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  • Author(s): Kalita J;Kalita J; Misra UK
  • Source:
    Journal of neurology [J Neurol] 2000 Dec; Vol. 247 (12), pp. 943-8.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print Cited Medium: Print ISSN: 0340-5354 (Print) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin ; New York, Springer-Verlag
    • Subject Terms:
      Evoked Potentials, Motor* ; Evoked Potentials, Somatosensory*; Myelitis, Transverse/*diagnosis ; Myelitis, Transverse/*physiopathology; Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Conduction ; Prognosis ; Tibial Nerve/physiopathology
    • Abstract:
      A systematic evaluation of anterior horn cell, motor and sensory pathways is possible by electromyography (EMG), motor (MEPs) and somatosensory (SEPs) evoked potentials, respectively, which may provide valuable information on acute transverse myelitis (ATM). In a prospective hospital-based study, EMG, MEP and SEP studies were carried out on admission and after 3 months in 39 patients with ATM. All the patients also underwent detailed clinical evaluation, and spinal magnetic resonance imaging (MRI) was performed in 28. Outcome was defined at the end of 3 months as poor, partial or complete recovery on the basis of functional status. Spinal MRI revealed hyperintense signal changes in T2 extending for two segments to the entire spinal cord. Central motor conduction time to tibialis anterior (CMCT-TA) was more frequently abnormal (90%), followed by tibial SEP (77%). CMCT to abductor digiti minimi (ADM) was abnormal in 30% and median SEP in 15% of patients. Evidence of denervation on EMG was present in 51% of patients. The CMCT-TA improved in 48% patients and tibial SEP in 32%. Median SEP improved in all patients, and CMCT-ADM remained prolonged in two. At 3 months 2 patients had died, and 18 had poor, 10 partial and 9 complete recovery. CMCT was correlated with muscle power, tone, reflex and MRI changes. Patients' outcome of was correlated with CMCT, SEP and EMG. These results are consistent with pronounced involvement of dorsal region of spinal cord in ATM. MEP is more frequently abnormal than SEP.
    • Publication Date:
      Date Created: 20010224 Date Completed: 20010322 Latest Revision: 20190831
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s004150070051
    • Accession Number:
      11200687