Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions.

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  • Author(s): Grant CM;Grant CM
  • Source:
    Molecular microbiology [Mol Microbiol] 2001 Feb; Vol. 39 (3), pp. 533-41.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print Cited Medium: Print ISSN: 0950-382X (Print) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-
    • Subject Terms:
      Oxidoreductases*; Glutathione/*metabolism ; Proteins/*metabolism ; Saccharomyces cerevisiae/*physiology ; Thioredoxins/*metabolism; Gene Expression Regulation, Fungal ; Glutaredoxins ; Glutathione/genetics ; Proteins/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Thioredoxins/genetics
    • Abstract:
      Sulphydryl groups (-SH) play a remarkably broad range of roles in the cell, and the redox status of cysteine residues can affect both the structure and the function of numerous enzymes, receptors and transcription factors. The intracellular milieu is usually a reducing environment as a result of high concentrations of the low-molecular-weight thiol glutathione (GSH). However, reactive oxygen species (ROS), which are the products of normal aerobic metabolism, as well as naturally occurring free radical-generating compounds, can alter this redox balance. A number of cellular factors have been implicated in the regulation of redox homeostasis, including the glutathione/glutaredoxin and thioredoxin systems. Glutaredoxins and thioredoxins are ubiquitous small heat-stable oxidoreductases that have proposed functions in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding and sulphur metabolism. This review describes recent findings in the lower eukaryote Saccharomyces cerevisiae that are leading to a better understanding of their role in redox homeostasis in eukaryotic cell metabolism.
    • Number of References:
      60
    • Accession Number:
      0 (Glutaredoxins)
      0 (Proteins)
      52500-60-4 (Thioredoxins)
      EC 1.- (Oxidoreductases)
      GAN16C9B8O (Glutathione)
    • Publication Date:
      Date Created: 20010213 Date Completed: 20010830 Latest Revision: 20220321
    • Publication Date:
      20240829
    • Accession Number:
      10.1046/j.1365-2958.2001.02283.x
    • Accession Number:
      11169096