Early neonatal brain injury in histologic chorioamnionitis.

Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print Cited Medium: Print ISSN: 0022-3476 (Print) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE

Original Publication: St. Louis, MO : Mosby

Brain Injuries/*etiology ; Cerebral Ventricles/*injuries ; Chorioamnionitis/*complications ; Chorioamnionitis/*pathology ; Histological Techniques/*standards ; Intracranial Hemorrhages/*etiology ; Leukomalacia, Periventricular/*etiology ; Seizures/*etiology; Age Factors ; Brain Injuries/diagnostic imaging ; Female ; Humans ; Infant, Newborn ; Intracranial Hemorrhages/diagnostic imaging ; Leukomalacia, Periventricular/diagnostic imaging ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Placenta/pathology ; Predictive Value of Tests ; Pregnancy ; Prospective Studies ; Risk Factors ; Seizures/diagnostic imaging ; Sensitivity and Specificity ; Single-Blind Method ; Ultrasonography, Doppler, Transcranial

The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).

Date Created: 20010110 Date Completed: 20010308 Latest Revision: 20190630

20240829

10.1067/mpd.2001.109605

11148520