Ex vivo synthesis of articular cartilage.

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  • Author(s): LeBaron RG;LeBaron RG; Athanasiou KA
  • Source:
    Biomaterials [Biomaterials] 2000 Dec; Vol. 21 (24), pp. 2575-87.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print Cited Medium: Print ISSN: 0142-9612 (Print) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
    • Publication Information:
      Publication: <1995-> : Amsterdam : Elsevier Science
      Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-
    • Subject Terms:
      Cartilage, Articular/*growth & development; Animals ; Biocompatible Materials
    • Abstract:
      This review discusses modern methods used for the synthesis of articular cartilage ex vivo. The value of culturing articular chondrocytes as a monolayer and in three-dimensional lattices is discussed. Of particular interest are techniques involving seeding of chondrocytes onto synthetic, biodegradable, polymeric scaffolds, and natural materials, such as collagen and agarose. Also discussed is the use of bioreactors to modulate the fluid-flow-induced shear environment of cell-seeded scaffolds. Biodegradable scaffolds are central to the efforts to tissue engineer articular cartilage ex vivo. A review of salient efforts to design and use such scaffolds is presented, along with our thoughts on potential future improvements.
    • Number of References:
      79
    • Accession Number:
      0 (Biocompatible Materials)
    • Publication Date:
      Date Created: 20001109 Date Completed: 20010301 Latest Revision: 20190815
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/s0142-9612(00)00125-3
    • Accession Number:
      11071607