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Diagnostic and prognostic relevance of autoantibodies in uranium miners.
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- Author(s): Conrad K;Conrad K; Mehlhorn J
- Source:
International archives of allergy and immunology [Int Arch Allergy Immunol] 2000 Sep; Vol. 123 (1), pp. 77-91.
- Publication Type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: S. Karger Country of Publication: Switzerland NLM ID: 9211652 Publication Model: Print Cited Medium: Print ISSN: 1018-2438 (Print) Linking ISSN: 10182438 NLM ISO Abbreviation: Int Arch Allergy Immunol Subsets: MEDLINE
- Publication Information:
Original Publication: Basel ; New York : S. Karger, 1992-
- Subject Terms:
Mining* ;
RNA, Small Cytoplasmic*;
Autoantibodies/
*blood ;
Occupational Diseases/
*immunology ;
Uranium/
*immunology;
Aged ;
Antibodies, Antinuclear/
blood ;
Autoantigens/
immunology ;
Cell Nucleolus/
immunology ;
Centromere/
immunology ;
DNA/
immunology ;
DNA Topoisomerases, Type I/
immunology ;
Female ;
Germany/
epidemiology ;
Humans ;
Lupus Erythematosus, Systemic/
diagnosis ;
Lupus Erythematosus, Systemic/
epidemiology ;
Lupus Erythematosus, Systemic/
mortality ;
Male ;
Occupational Diseases/
diagnosis ;
Occupational Diseases/
epidemiology ;
Occupational Diseases/
mortality ;
Organ Specificity/
immunology ;
Prognosis ;
Ribonucleoproteins/
immunology ;
Ribonucleoproteins, Small Nuclear/
immunology ;
Scleroderma, Systemic/
diagnosis ;
Scleroderma, Systemic/
epidemiology ;
Scleroderma, Systemic/
mortality ;
Silicon Dioxide/
immunology ;
SS-B Antigen - Abstract:
Uranium miners exposed to silica dust have a higher risk of developing systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). Sera of 1976 former uranium miners were analysed for autoantibodies typical of connective tissue disease. The frequency of some of these antibodies (anti-centromere, -topoisomerase I, -nucleolar, -dsDNA, -Ro/SSA, -La-SSB and U1-RNP antibodies) was significantly higher compared to a gender- and age-matched control group and was associated with the intensity of exposure as well as with clinical symptoms of SSc or SLE. It was also shown that SSc-associated autoantibodies may serve as an early indicator of disease development. Some differences in the autoantibody production between silica-dust-associated and idiopathic SLE/SSc were observed that might be caused by environmental factors in the population of uranium miners.
(Copyright 2000 S. Karger AG, Basel.)
- Accession Number:
0 (Antibodies, Antinuclear)
0 (Autoantibodies)
0 (Autoantigens)
0 (RNA, Small Cytoplasmic)
0 (RO60 protein, human)
0 (Ribonucleoproteins)
0 (Ribonucleoproteins, Small Nuclear)
0 (SS-A antigen)
4OC371KSTK (Uranium)
7631-86-9 (Silicon Dioxide)
9007-49-2 (DNA)
EC 5.99.1.2 (DNA Topoisomerases, Type I)
- Publication Date:
Date Created: 20001003 Date Completed: 20001106 Latest Revision: 20231213
- Publication Date:
20231215
- Accession Number:
10.1159/000024426
- Accession Number:
11014974
No Comments.