[Water channels of the cell--aquaporins].

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  • Author(s): Forslund T;Forslund T; Iversen BM
  • Source:
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2000 Aug 10; Vol. 120 (18), pp. 2129-34.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Norwegian
  • Additional Information
    • Transliterated Title:
      Cellenes vannporer--akvaporinene.
    • Source:
      Publisher: Norske Laegeforening Country of Publication: Norway NLM ID: 0413423 Publication Model: Print Cited Medium: Print ISSN: 0029-2001 (Print) Linking ISSN: 00292001 NLM ISO Abbreviation: Tidsskr Nor Laegeforen Subsets: MEDLINE
    • Publication Information:
      Publication: Oslo : Norske Laegeforening
      Original Publication: Chistiania : Alb. Cammermeyer, 1880-
    • Subject Terms:
      Aquaporins/*physiology; Aquaporins/chemistry ; Aquaporins/metabolism ; Body Water/physiology ; Diabetes Insipidus/metabolism ; Diabetes Insipidus/physiopathology ; Humans ; Molecular Structure ; Nephrotic Syndrome/metabolism ; Nephrotic Syndrome/physiopathology ; Renal Insufficiency/metabolism ; Renal Insufficiency/physiopathology ; Terminology as Topic ; Water-Electrolyte Balance/physiology ; Water-Electrolyte Imbalance/metabolism ; Water-Electrolyte Imbalance/physiopathology
    • Abstract:
      Background: Several mechanisms in the body regulate the water transport within the cells up and down during physiological and pathological conditions. The discovery of aquaporins, water channel proteins, has brought more insight into and understanding of how water crosses plasma membranes within cells in body tissue.
      Material and Methods: The functions of aquaporins are not fully understood; this paper summarise current knowledge of various aquaporins.
      Results: Known aquaporins are discussed in relation to some physiological, pathological and clinical conditions.
      Interpretation: In the future, measurements of aquaporin concentrations in urine and possibly in other samples will give us a broader picture of water exchange and a better understanding of the mechanisms underlying water production in clinical states like renal and heart failure and liver insufficiency. Moreover, by manipulating water channel proteins by compounds developed for this purpose, one may have a tool for treating some clinical disorders in which water depletion or water overload is an important factor.
    • Number of References:
      37
    • Accession Number:
      0 (Aquaporins)
    • Publication Date:
      Date Created: 20000928 Date Completed: 20001016 Latest Revision: 20101118
    • Publication Date:
      20231215
    • Accession Number:
      11006732