[Prevalence of APO e4 allele in Israeli ethnic groups].

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  • Additional Information
    • Source:
      Publisher: Israel Medical Association Country of Publication: Israel NLM ID: 0034351 Publication Model: Print Cited Medium: Print ISSN: 0017-7768 (Print) Linking ISSN: 00177768 NLM ISO Abbreviation: Harefuah Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tel Aviv : Israel Medical Association
    • Subject Terms:
      Gene Frequency*; Apolipoproteins E/*genetics ; Ethnicity/*genetics ; Jews/*genetics; Africa/ethnology ; Alleles ; Alzheimer Disease/genetics ; Apolipoprotein E4 ; Coronary Artery Disease/genetics ; Europe/epidemiology ; Humans ; Israel ; Risk Factors
    • Abstract:
      The 4 allele of the APOE gene, coding for apo-lipoprotein E, is the most common genetic risk factor for Alzheimer's disease and a significant risk factor for coronary atherosclerosis. There is therefore much interest in studying its frequency in different ethnic groups. We examined its frequency in Jews originating from Libya, Buchara and Ethiopia and in Jews of Sepharadi and Ashkenazi origins. Its frequency among Ethiopian immigrants was 0.27, significantly higher than in the other groups, in which the frequency was between 0.067 and 0.10. These differences in allele frequency may serve as a basis for future studies in Israel to assess the relative contributions of genetic and environmental factors to the incidence of dementia.
    • Accession Number:
      0 (Apolipoprotein E4)
      0 (Apolipoproteins E)
    • Publication Date:
      Date Created: 20000824 Date Completed: 20000919 Latest Revision: 20211203
    • Publication Date:
      20231215
    • Accession Number:
      10955124