Intake of dietary folate and folic acid in Germany based on different scenarios for food fortification with folic acid.

ENRICHED foods; CHI-squared test; COMPARATIVE studies; CONFIDENCE intervals; DIETARY supplements; EPIDEMIOLOGICAL research; FOLIC acid; INGESTION; NUTRITION; NUTRITIONAL assessment; NUTRITIONAL requirements; NUTRITION policy; PROBABILITY theory; PUBLIC health; RESEARCH funding; SURVEYS; DATA analysis software; DESCRIPTIVE statistics

Purpose: Besides the adverse health effects of a low folate intake, the risks of high intakes of folic acid have moved into the focus. The aim of this study was to investigate the potential range of folate and folic acid intake of the German population under consideration of different fortification scenarios. Methods: Food consumption data of 13,926 participants of the German National Nutrition Survey II (NVS II), collected with two 24-h recalls, were used to calculate the nutrient intake. The nutrient data are based on the German Nutrient Database (BLS), information from a market survey and analyses of multivitamin juices. The scenarios were modelled without, as well as with low and high fortification levels of folic acid. Results: The median intake of dietary folate equivalents ranged from 191 µg/d (men) and 168 µg/d (women) without fortification to 425 µg/d (men) and 334 µg/d (women) in the highest fortification scenario. Thus, 12.4-68.2 % (men) and 5.9-56.1 % (women) met the 300 µg/d recommended by the nutrition societies of Germany, Austria and Switzerland. In the highest fortification scenario, 1.9 % (men) and 0.8 % (women) exceeded the tolerable upper intake level (UL) of 1,000 µg/d folic acid given by the European Food Safety Authority. For supplement users, this proportion was 5.2 and 5.4 %. Conclusions: Only a high fortification of several foods leads to a marked increase of the proportion of population reaching the recommendation. Simultaneously, with a high fortification a higher proportion exceeds the UL, especially in combination with supplements. [ABSTRACT FROM AUTHOR]