[The effect of panpal prophylaxis on acetylcholinesterase activity in the blood, diaphragm and various parts of the brain in rats during treated and untreated poisoning with the organophosphorus insecticide phosdrine]].

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  • Author(s): Kassa J;Kassa J
  • Source:
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti [Ceska Slov Farm] 2000 Jan; Vol. 49 (1), pp. 37-40.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Vliv profylaxe panpalem na aktivitu acetylcholinesterázy v krvi, bránici a různých cástech mozku potkana v průbĕhu nelécené a lécené intoxikace organofosforovým insekticidem fosdrinem.
    • Source:
      Publisher: Ceská lékarská spolecnost J. E. Purkyne Country of Publication: Czech Republic NLM ID: 9433765 Publication Model: Print Cited Medium: Print ISSN: 1210-7816 (Print) Linking ISSN: 12107816 NLM ISO Abbreviation: Ceska Slov Farm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceská lékarská spolecnost J. E. Purkyne,
    • Subject Terms:
      Acetylcholinesterase/*metabolism ; Benactyzine/*pharmacology ; Insecticides/*toxicity ; Mevinphos/*toxicity ; Pyridostigmine Bromide/*pharmacology ; Trihexyphenidyl/*pharmacology; Acetylcholinesterase/blood ; Animals ; Antidotes/therapeutic use ; Atropine/therapeutic use ; Brain/metabolism ; Cholinesterase Reactivators/therapeutic use ; Diaphragm/metabolism ; Drug Combinations ; Male ; Oximes ; Pyridinium Compounds/therapeutic use ; Rats ; Rats, Wistar
    • Abstract:
      In experiments on male rats the paper investigated the effect of pharmacological prophylaxis with Panpal (pyridostigmine in combination with benactyzine and trihexyphenidyl) on the activity of acetylcholinesterase in the whole blood, diaphragm, and selected parts of the brain (frontal cortex, pontomedular region, hippocampus, cerebellum) at hour 1 and 3 of untreated and treated (oxime HI-6 with atropine) intoxication with the organophosphorous insecticide phosdrine. Whereas in the CNS Panpal did not produce statistically significant changes in the activity of acetylcholinesterase in the course of untreated and treated phosdrine intoxication, in the blood and diaphragm Panpal markedly intensified phosdrine-induced inhibition of the acetylcholinesterase activity and, in addition, decreased the reactivating effect of the oxime HI-6. The data give evidence of the importance of the combination of the prophylactically used reversible acetylcholinesterase inhibitor pyridostigmine with anticholinergics, which could eliminate the consequences of a pyridostigmine-induced decrease in the activity of the enzyme in the periphery.
    • Accession Number:
      0 (Antidotes)
      0 (Cholinesterase Reactivators)
      0 (Drug Combinations)
      0 (Insecticides)
      0 (Oximes)
      0 (Pyridinium Compounds)
      0 (panpal)
      595EG71R3F (Benactyzine)
      6RC5V8B7PO (Trihexyphenidyl)
      7786-34-7 (Mevinphos)
      7C0697DR9I (Atropine)
      EC 3.1.1.7 (Acetylcholinesterase)
      HUV88P6SJS (asoxime chloride)
      KVI301NA53 (Pyridostigmine Bromide)
    • Publication Date:
      Date Created: 20000823 Date Completed: 20001124 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      10953441