The 1438G/A polymorphism of the 5-HT[sub 2A] receptor gene is associated with aura in migraine.

Objective: To find out the role of the 1438G/A polymorphism of the 5-HT[sub 2A ]promoter region in migraine. Study design: A polymerase chain reaction (PCR) analysis of the 1438G/A polymorphism was performed in 61 migraineurs and 57 healthy controls. Methods: The results of 1438G/A polymorphism were compared between the migraineurs and controls as well as between migraineurs with aura (MA) and those without aura (MOA). Results: The 1438 G/A polymorphism of 5-HT[sub 2A] receptor gene was similar in both migraineurs and controls (p = 0.6). There was a significant relationship between the presence of G/G genotype and MA (p = 0.02) while A/A and A/G genotypes were similar in both MA and MOA (p > 0.05). Conclusion: The 1438G/A polymorphism of the 5-HT[sub 2A] receptor gene is not associated with increased risk of migraine. The polymorphism of the gene is involved in determining the type of migraine. MA and MOA seem to be genetically distinct disorders. [ABSTRACT FROM AUTHOR]

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