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Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice.
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- Author(s): Hamilton JD; Elliott DM
- Source:
The Journal of infectious diseases [J Infect Dis] 1975 Feb; Vol. 131 (2), pp. 129-37.
- Publication Type:
Comparative Study; Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
- Publication Information:
Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
- Subject Terms:
- Abstract:
The in vitro and in vivo activities of amphotericin B and 5-fluorocytosine (5-FC) alone and in combination were studied to determine possible drug interactions against two strains of Cryptococcus neoformans, one sensitive to 5-FC and one resistant to 5-FC. In vitro tube dilution studies demonstrated only additive effects with the 5-FC-sensitive organism but antagonism with eth 5-FC-resistant organism. A mouse model of cryptococcal meningitis allowed comparative drug trails in a new model for the detection of drug interactions. Drug combinations were no more effective against meningitis caused by the 5-FC-sensitive organism than the additive effects of the individual drugs. However, meningitis caused by the 5-FC-resistant Cryptococcus responded less to drug combinations than to either drug alone. Serum levels of amphotericin B and 5-FC were comparable in all groups. No evidence of toxicity from the drug combinations was found. No inhibition of development of resistance to 5-FC by the combination with amphotericin B was detected.
- Accession Number:
7XU7A7DROE (Amphotericin B)
8J337D1HZY (Cytosine)
D83282DT06 (Flucytosine)
- Publication Date:
Date Created: 19750201 Date Completed: 19750528 Latest Revision: 20190509
- Publication Date:
20221208
- Accession Number:
10.1093/infdis/131.2.129
- Accession Number:
1090685
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