Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues.

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  • Additional Information
    • Source:
      Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
    • Publication Information:
      Publication: Baltimore, Md. : American Association for Cancer Research
      Original Publication: Chicago [etc.]
    • Subject Terms:
      Prostatic Neoplasms/*metabolism ; Protein Serine-Threonine Kinases/*biosynthesis ; Receptors, Growth Factor/*biosynthesis; Blotting, Western ; Bone Morphogenetic Protein Receptors, Type I ; Bone Morphogenetic Protein Receptors, Type II ; Disease Progression ; Epithelial Cells/metabolism ; Humans ; Immunohistochemistry ; Male ; Prostate/metabolism ; Prostatic Neoplasms/pathology ; Transforming Growth Factors/metabolism
    • Abstract:
      Bone morphogenetic proteins (BMPs) are potential regulators of prostate cancer cell growth and metastasis that signal through an interaction with BMP membrane receptors (BMPRs) type I and type II. In the present study, Western blot and immunohistochemical analysis of BMPRs were carried out in benign and malignant human prostate tissues to explain the loss of BMP response in human prostate cancer cells. The results demonstrated that the benign prostate specimens expressed high levels of all three BMPRs. In normal prostate, BMPRs were localized predominantly to epithelial cells. Among prostate cancer specimens, well-differentiated cancers were positive for the expression of BMPR-II, BMPR-IA, and BMPR-IB, for the most part. In contrast, only 1 of 10 poorly differentiated prostate cancer cases was positive for each of the three BMPRs (P < 0.005 for all three receptors). Taken together, these results indicate that human prostate cancer cells frequently exhibit loss of expression of BMPRs and suggest that loss of BMPRs may play an important role during the progression of prostate cancer.
    • Grant Information:
      58204 United States PHS HHS
    • Accession Number:
      0 (Receptors, Growth Factor)
      76057-06-2 (Transforming Growth Factors)
      EC 2.7.11.1 (Protein Serine-Threonine Kinases)
      EC 2.7.11.30 (BMPR1A protein, human)
      EC 2.7.11.30 (BMPR1B protein, human)
      EC 2.7.11.30 (BMPR2 protein, human)
      EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type I)
      EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type II)
    • Publication Date:
      Date Created: 20000613 Date Completed: 20000630 Latest Revision: 20211203
    • Publication Date:
      20240829
    • Accession Number:
      10850425