Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids (review).

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  • Author(s): McConville MJ;McConville MJ; Menon AK
  • Source:
    Molecular membrane biology [Mol Membr Biol] 2000 Jan-Mar; Vol. 17 (1), pp. 1-16.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9430797 Publication Model: Print Cited Medium: Print ISSN: 0968-7688 (Print) Linking ISSN: 09687688 NLM ISO Abbreviation: Mol Membr Biol Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London, UK : Taylor & Francis, c1994-2019.
    • Subject Terms:
      Glycosylphosphatidylinositols/*metabolism ; Intracellular Membranes/*metabolism; Animals ; Endoplasmic Reticulum/chemistry ; Endoplasmic Reticulum/metabolism ; Eukaryotic Cells/chemistry ; Eukaryotic Cells/metabolism ; Glycosylphosphatidylinositols/biosynthesis ; Glycosylphosphatidylinositols/chemistry ; Intracellular Membranes/chemistry ; Species Specificity ; Subcellular Fractions/chemistry ; Subcellular Fractions/metabolism
    • Abstract:
      Glycosylphosphatidylinositols (GPIs) represent an abundant and ubiquitous class of eukaryotic glycolipids. Although these structures were originally discovered in the form of GPI-anchored cell surface glycoproteins, it is becoming increasingly clear that a significant proportion of the GPI synthetic output of a cell is not directed to protein anchoring. Indeed, pools of non-protein-linked GPIs can approach 10(7) molecules per cell in some cell types, especially the protozoa, with a large proportion of these molecules being displayed at the cell surface. Recent studies which form the subject of this review indicate that there is (a) considerable diversity in the range of structural modifications found on GPI glycolipids within and between species and cell types, (b) complexity in the topological arrangement of the GPI biosynthetic pathway in the endoplasmic reticulum, and (c) spatial restriction of the biosynthetic pathway within the endoplasmic reticulum. Furthermore, consistent with additional functional roles for these lipids beyond serving as protein anchor precursors, products of the GPI biosynthetic pathway appear to be widely distributed in the cellular endomembrane system. These studies indicate that there is still much to learn about the organization of glycolipid biosynthetic pathways in eukaryotic cells, the nature and subcellular distribution of the lipid products of these pathways, and the function of these lipids within cells.
    • Number of References:
      127
    • Grant Information:
      GM55427 United States GM NIGMS NIH HHS
    • Accession Number:
      0 (Glycosylphosphatidylinositols)
    • Publication Date:
      Date Created: 20000529 Date Completed: 20000731 Latest Revision: 20191104
    • Publication Date:
      20221213
    • Accession Number:
      10.1080/096876800294443
    • Accession Number:
      10824734