Regulation of the G1 phase of the mammalian cell cycle.

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  • Author(s): Donjerkovic D;Donjerkovic D; Scott DW
  • Source:
    Cell research [Cell Res] 2000 Mar; Vol. 10 (1), pp. 1-16.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print Cited Medium: Print ISSN: 1001-0602 (Print) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE
    • Publication Information:
      Publication: Basingstoke, England : Nature Publishing Group
      Original Publication: Beijing, China : Science Press, 1990-
    • Subject Terms:
      G1 Phase/*physiology; Animals ; Humans
    • Abstract:
      In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the G1 phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family, cyclin dependent kinases, cyclins, and cyclin kinase inhibitors.
    • Number of References:
      122
    • Grant Information:
      CA55644 United States CA NCI NIH HHS
    • Publication Date:
      Date Created: 20000415 Date Completed: 20000602 Latest Revision: 20230120
    • Publication Date:
      20240829
    • Accession Number:
      10.1038/sj.cr.7290031
    • Accession Number:
      10765979