Cannabinoid Agonists and Antagonists Modulate Lithium-induced Conditioned Gaping in Rats.

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    • Subject Terms:
      CLASSICAL conditioning; CONDITIONED response; NAUSEA; VOMITING; CANNABINOIDS
    • Abstract:
      Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, Δ-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB 1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea. [ABSTRACT FROM AUTHOR]
    • Abstract:
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