Person-specific paths of cognitive decline in Alzheimer's disease and their relation to age.

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  • Additional Information
    • Source:
      Publisher: American Psychological Association Country of Publication: United States NLM ID: 8904079 Publication Model: Print Cited Medium: Print ISSN: 0882-7974 (Print) Linking ISSN: 08827974 NLM ISO Abbreviation: Psychol Aging Subsets: MEDLINE
    • Publication Information:
      Original Publication: Arlington, VA : American Psychological Association, [c1986-
    • Subject Terms:
      Alzheimer Disease/*diagnosis ; Cognition Disorders/*diagnosis ; Psychological Tests/*statistics & numerical data; Adult ; Age Factors ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Cognition Disorders/psychology ; Confidence Intervals ; Factor Analysis, Statistical ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychometrics
    • Abstract:
      Change in global and specific measures of cognitive function was studied in a cohort of 410 persons with Alzheimer's disease. Persons completed up to 5 annual evaluations; follow-up participation among survivors exceeded 90%. Average annual decline was 0.57 standard score units (95% confidence interval [CI]: -0.51 to -0.62) on a composite measure based on 17 individual tests and 3.26 points (95% CI: -3.06 to 3.46) on the Mini-Mental State Examination, but substantial heterogeneity was apparent. On both global and specific measures, rate of cognitive decline was reduced in older persons compared with younger persons. A similar effect was observed for estimated age of disease onset. The effect of age was approximately linear and was not attributable to education, sex, race, other conditions that impair cognition, or mortality. The results indicate that person-specific paths of cognitive decline in Alzheimer's disease vary substantially and suggest that in clinical settings some of this variability is related to age.
    • Grant Information:
      P30 AG10161 United States AG NIA NIH HHS; R01 AG09966 United States AG NIA NIH HHS
    • Publication Date:
      Date Created: 20010207 Date Completed: 20000428 Latest Revision: 20191025
    • Publication Date:
      20231215
    • Accession Number:
      10.1037//0882-7974.15.1.18
    • Accession Number:
      10755286