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FACT Facilitates Transcription-Dependent NucleosomeAlteration.
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- Author(s): Belotserkovskaya, Rimma; Oh, Sangtaek; Bondarenko, Vladimir A.; Orphanides, George; Studitsky, Vasily M.; Reinberg, Danny
- Source:
Science. 8/22/2003, Vol. 301 Issue 5636, p1090-1093. 4p. 4 Diagrams. - Source:
- Additional Information
- Subject Terms:
- Abstract: The FACT (facilitates chromatin transcription) complex is required for transcript elongation through nucleosomes by RNA polymerase II (Pol II) in vitro. Here, we show that FACT facilitates Pol II-driven transcription by destabilizing nucleosomal structure so that one histone H2A-H2B dimer is removed during enzyme passage. We also demonstrate that FACT possesses intrinsic histone chaperone activity and can deposit core histones onto DNA. Importantly, FACT activity requires both of its constituent subunits and is dependent on the highly acidic C terminus of its larger subunit, Spt16. These findings define the mechanism by which Pol II can transcribe through chromatin without disrupting its epigenetic status. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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