Circadian variations in plasma and erythrocyte glutamate concentrations in adult men consuming a diet with and without added monosodium glutamate.

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  • Author(s): Tsai PJ;Tsai PJ; Huang PC
  • Source:
    The Journal of nutrition [J Nutr] 2000 Apr; Vol. 130 (4S Suppl), pp. 1002S-4S.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print Cited Medium: Print ISSN: 0022-3166 (Print) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : [New York, NY] : Elsevier
      Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas
    • Subject Terms:
      Circadian Rhythm/*drug effects ; Erythrocytes/*metabolism ; Food Additives/*pharmacology ; Glutamic Acid/*blood ; Sodium Glutamate/*pharmacology; Adult ; Amino Acids/blood ; Humans ; Male ; Osmolar Concentration ; Reference Values
    • Abstract:
      This study evaluated the effect of monosodium glutamate (MSG) ingestion as a component of the diet on the 24-h variations in plasma and whole-blood glutamate (GLU) concentrations in healthy adult men. In the first arm of the study, subjects were given test meals without added MSG for 3 d. Protein and energy intakes of the subjects were 1.5 g and 40 kcal/(kg body weight.d), respectively. On d 3, blood samples were collected over the 24-h period. One week later, the same protocol was repeated, except that 100 mg/(kg body weight.d) MSG was added to the meals (15, 40 and 45 mg/kg body weight to breakfast, lunch and dinner, respectively). Both plasma and whole-blood samples were analyzed for free amino acids. Unlike large neutral amino acids, which experienced high peak plasma concentrations at 2100-2300 h, the circadian variations in plasma GLU concentrations were small, varying between 33 and 48 micromol/L on days in which no MSG was fed, and between 32 and 53 micromol/L on days in which MSG was added to the meals. In both trials, plasma GLU concentration increased (P < 0.01) after lunch and dinner, and decreased early in the morning (P < 0.05). Calculated erythrocyte GLU concentrations varied between 500 and 640 micromol/L, with or without MSG addition to the meals. The rather low plasma GLU concentrations over the 24-h period, despite high dietary intake of MSG, indicate that dietary MSG is metabolized very rapidly.
    • Accession Number:
      0 (Amino Acids)
      0 (Food Additives)
      3KX376GY7L (Glutamic Acid)
      W81N5U6R6U (Sodium Glutamate)
    • Publication Date:
      Date Created: 20000329 Date Completed: 20000425 Latest Revision: 20180506
    • Publication Date:
      20240829
    • Accession Number:
      10.1093/jn/130.4.1002S
    • Accession Number:
      10736370