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Simultaneous determination of sulfaquinoxaline, sulfamethazine and pyrimethamine by liquid chromatography.
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- Additional Information
- Source:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print Cited Medium: Print ISSN: 0021-9673 (Print) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
- Publication Information:
Original Publication: Amsterdam ; New York : Elsevier, 1993-
- Subject Terms:
- Abstract:
A liquid chromatography method is described to determine sulfaquinoxaline (SQX), sulfamethazine (SMT), and pyrimethamine (PMT), by using a Kromasil C18 column and a 40 mM NaH2PO4 buffer solution, containing 10 mM NaClO4 (pH 3.0)-acetonitrile (65:35) as mobile phase. The mobile phase flow-rate and sample volume injected were 1.5 ml/min and 20 microl, respectively and the samples were dissolved in the mobile phase. The limits of quantification were found to be about 180 microg/l (3.6 ng) for each compound. The method was applied in veterinary commercial formulations. Analyses were made by means of the standard addition method, whose results were compared with those obtained by preparing "tests" (from the stock solutions) and with those obtained by a capillary electrophoresis method. Both methods showed similar results, and then it was proved that some commercial claimed levels were not in agreement with the obtained results by using our analytical method, as they were in other cases.
- Accession Number:
0 (Anti-Infective Agents)
48U51W007F (Sulfamethazine)
WNW8115TM9 (Sulfaquinoxaline)
Z3614QOX8W (Pyrimethamine)
- Publication Date:
Date Created: 20000318 Date Completed: 20000418 Latest Revision: 20190720
- Publication Date:
20231215
- Accession Number:
10.1016/s0021-9673(99)00880-8
- Accession Number:
10722074
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