Changes in several functions of murine peritoneal macrophages by N-acetylcysteine and thioproline ingestion. Comparative effect between two strains of mice.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print Cited Medium: Print ISSN: 0951-6433 (Print) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Ios Press
      Original Publication: Oxford ; Washington, DC : Published for the International Union of Biochemistry by IRL Press, [c1988-
    • Subject Terms:
      Acetylcysteine/*pharmacology ; Antioxidants/*pharmacology ; Macrophages, Peritoneal/*physiology ; Phagocytosis/*drug effects ; Thiazoles/*pharmacology; Acetylcysteine/administration & dosage ; Animals ; Antioxidants/administration & dosage ; Cell Adhesion/drug effects ; Chemotaxis/drug effects ; Dietary Supplements ; Female ; In Vitro Techniques ; Interleukin-1/biosynthesis ; Macrophages, Peritoneal/cytology ; Macrophages, Peritoneal/drug effects ; Mice ; Mice, Inbred BALB C ; Species Specificity ; Superoxides/metabolism ; Thiazoles/administration & dosage ; Thiazolidines
    • Abstract:
      The administration of the thiol compounds, N-acetylcysteine (NAC) and in particular thioproline (thiazolidine-4-carboxylic acid) at 0.1% w/w concentration in the diet, improves lymphocyte functions in old female Swiss mice, as has been shown in our previous studies. In the present work, adult mice from two different strains, namely BALB/c (an inbred strain) and OF1-Swiss (noninbred strain), were fed a diet supplemented with the above dose of each thiol compound jointly for five weeks. At 28 weeks of age, peritoneal cell suspensions were obtained and different steps of the phagocytic process, the most representative activity of macrophages, as well as interleukin-1beta (IL-1beta) production, were studied. Thus, adherence to substrate, mobility directed to a chemoattractant gradient (chemotaxis), ingestion of inert particles and superoxide anion production were analysed. The results show that diet supplementation with NAC plus thioproline increased all macrophage functions studied with the exception of superoxide anion production, which was decreased. These effects were more evident in macrophages from Swiss mice, whereas in BALB/c mice the stimulation of phagocytosis and IL-1beta production was lower and no differences were seen after treatment in adherence and superoxide anion production. These data suggest that immune function can be improved in adult mice by administration of the above thiol compounds, especially in the noninbred strain of OF1-Swiss mice.
    • Accession Number:
      0 (Antioxidants)
      0 (Interleukin-1)
      0 (Thiazoles)
      0 (Thiazolidines)
      11062-77-4 (Superoxides)
      E5913T3IBL (thiazolidine-4-carboxylic acid)
      WYQ7N0BPYC (Acetylcysteine)
    • Publication Date:
      Date Created: 19991228 Date Completed: 20000201 Latest Revision: 20191024
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/biof.5520100214
    • Accession Number:
      10609880