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Lack of Association of catechol-O-Methyltransferase Gene Polymorphism in ObsessiveCompulsive Disorder.
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- Author(s): M. Emin Erdal; Şenel Tot; Kemal Yazıcı; Aylin Yazıcı; Hasan Herken; Pervin Erdem; Ebru Derici; Handan Çamdeviren
- Source:
Depression & Anxiety (1091-4269). 2003, Vol. 18 Issue 1, p41-45. 5p. - Source:
- Additional Information
- Subject Terms:
- Abstract: The COMT gene has been implicated to be involved in the pathogenesis of obsessivecompulsive disorder (OCD) and various other psychiatric disorders. COMT enzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity variant (L)]. This study evaluates the association between OCD and the COMT gene polymorphism. Fifty-nine OCD patients that were diagnosed according to DSM-IV criteria and 114 healthy control subjects were included in the study. PCR technique was used for molecular analysis. The genotypic pattern of distribution of the COMT gene (H/H, H/L, and L/L genotypes) was not different between the OCD patients and controls. There were no significant differences among the patients with positive family history for OCD, those with negative family history for OCD, and the controls with respect to allele frequencies of the COMT gene polymorphisms. Patients that were homozygous or heterozygous for the L allele had significantly higher insight scores (i.e., poorer insight) on Y-BOCS compared to those homozygous for the H allele. We did not find an association between OCD, family history for OCD, and the COMT gene polymorphism. This study suggests that the COMT gene polymorphism is not directly associated with OCD in our patient group. Depression and Anxiety 18:4145, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Depression & Anxiety (1091-4269) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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