Evaluation of the correlation between plasma amylase and lipase levels and phthalate exposure in pubertal gynecomastia patients. (Turkish)

Aim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and a-amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas.Material and Method: The study group was composed of 40 pubertal gynecomastia patients. Plasma phthalate levels (Di(2-ethylhexyl)phthalate, DEHP and mono (2-ethylhexyl) phthalate, MEHP) were determined using HPLC. Plasma lipase and a-amylase levels were measured by using enzymatic colorimetric assay. Results: Plasma DEHP and MEHP levels in gynecomatia patients were higher than the control group significantly. Significant negative correlations existed between a-amylase and MEHP levels in gynecomastia (r=-0.388, p<0.05) and overall study groups (r=-0.353, p<0.05). Negative correlation between DEHP and a-amylase levels was found to be significant in overall study group (r=-0.323, p<0.05). Conclusions: The results suggest that phthalate exposure might cause significant decreases in a-amylase secretion. The inverse correlation observed might be explained by the PPARg (peroxisome proliferator-activated receptor gamma)-activation of phthalates. [ABSTRACT FROM AUTHOR]

Copyright of Türk Pediatri Arşivi is the property of Aves Yayincilik Ltd. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)