[A comparison of alpha 1-acid glycoprotein (AAG) concentration and disopyramide binding in Chinese and Japanese].

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  • Author(s): Jin EZ;Jin EZ
  • Source:
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science [Hokkaido Igaku Zasshi] 1999 Jul; Vol. 74 (4), pp. 279-88.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Hokkaidō Igakkai Country of Publication: Japan NLM ID: 17410290R Publication Model: Print Cited Medium: Print ISSN: 0367-6102 (Print) Linking ISSN: 03676102 NLM ISO Abbreviation: Hokkaido Igaku Zasshi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Sapporo, Hokkaidō Igakkai.
    • Subject Terms:
      Anti-Arrhythmia Agents/*metabolism ; Disopyramide/*metabolism ; Orosomucoid/*metabolism; Adult ; Asian People ; Binding Sites ; China ; Female ; Humans ; Japan ; Male ; Protein Binding ; Sex Factors
    • Abstract:
      The mean concentration of alpha 1-acid glycoprotein (AAG) in plasma and disopyramine binding capacity to AAG (bound disopyramine/AAG) were compared between fourteen Chinese and sixteen Japanese subjects. As a results, the author observed that the mean AAG-concentrations in Chinese and in Japanese were 0.55 +/- 0.11 mg/ml and 0.64 +/- 0.13 mg/ml, respectively. When disopyramine concentration was at 5.0 micrograms/ml, the bound disopyramine/AAG was 7.3 +/- 1.3 micrograms/mg in Chinese and 6.5 +/- 1.3 micrograms/mg in Japanese. Unbound fractions of disopyramine in Chinese and Japanese were 0.23 +/- 0.05% and 0.19 +/- 0.07%, respectively. These results indicated that there was no significant difference in the AAG-concentration and the bound disopyramine/AAG between Chinese and Japanese subjects. In male subjects, however, the AAG-concentration and the bound disopyramine/AAG in Chinese (0.57 +/- 0.14 mg/ml and 7.47 +/- 1.78 micrograms/mg) were significantly different from those in Japanese (0.72 +/- 0.11 mg/ml and 5.84 +/- 0.76 micrograms/mg, p < 0.05), though unbound fraction of disopyramide was not found different between Chinese and Japanese subjects. In female, the AAG-concentration, the bound disopyramine/AAG and unbound fraction of disopyramide did not significantly differ between Chinese and Japanese subjects. These findings suggest a possible structural difference of monosaccharides in plasma-AAG between Chinese and Japanese male subjects.
    • Accession Number:
      0 (Anti-Arrhythmia Agents)
      0 (Orosomucoid)
      GFO928U8MQ (Disopyramide)
    • Publication Date:
      Date Created: 19990910 Date Completed: 19990930 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      10480035