Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.

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  • Author(s): Mahley RW;Mahley RW; Huang Y
  • Source:
    Current opinion in lipidology [Curr Opin Lipidol] 1999 Jun; Vol. 10 (3), pp. 207-17.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9010000 Publication Model: Print Cited Medium: Print ISSN: 0957-9672 (Print) Linking ISSN: 09579672 NLM ISO Abbreviation: Curr Opin Lipidol Subsets: MEDLINE
    • Publication Information:
      Publication: London : Lippincott Williams & Wilkins
      Original Publication: London, UK : Current Science, c1990-
    • Subject Terms:
      Alzheimer Disease/*metabolism ; Apolipoproteins E/*metabolism ; Arteriosclerosis/*metabolism; Apolipoproteins E/chemistry ; Humans ; Nervous System Diseases/metabolism
    • Abstract:
      Apolipoprotein E is a key regulator of plasma lipid levels. Our appreciation of its role continues to expand as additional aspects of its function are discovered. Apolipoprotein E affects the levels of all lipoproteins, either directly or indirectly by modulating their receptor-mediated clearance or lipolytic processing and the production of hepatic very low density lipoproteins. Furthermore, it plays a critical role in neurobiology. The apolipoprotein E4 allele is the major susceptibility gene related to the occurrence and early age of onset of Alzheimer's disease. It is probable that one of the major functions of apolipoprotein E in the central nervous system is to mediate neuronal repair, remodeling, and protection, with apolipoprotein E4 being less effective than the E3 and E2 alleles. The isoform-specific effects of apolipoprotein E are currently being unraveled through detailed structure and function studies of this protein.
    • Number of References:
      99
    • Grant Information:
      HL47660 United States HL NHLBI NIH HHS
    • Accession Number:
      0 (Apolipoproteins E)
    • Publication Date:
      Date Created: 19990804 Date Completed: 19990922 Latest Revision: 20220309
    • Publication Date:
      20240829
    • Accession Number:
      10.1097/00041433-199906000-00003
    • Accession Number:
      10431657