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Particulate air pollution and circulating biomarkers among type 2 diabetic mellitus patients: the roles of particle size and time windows of exposure.
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- Author(s): Wang, Cuicui1,2; Chen, Renjie1,2; Zhao, Zhuohui1; Cai, Jing1,2; Lu, Jianxiong3; Ha, Sandie1,2,3; Xu, Xiaohui1,2,3; Chen, Xuan3; Kan, Haidong1,2
- Source:
Environmental Research. Jul2015, Vol. 140, p112-118. 7p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Background Short-term associations between size-fractionated particulate matter (PM) air pollution and circulating biomarkers are not well established, especially among diabetes patients. Methods We conducted a longitudinal panel study involving 6 repeated measurements of 12 circulating biomarkers among 35 diabetes patients from April to June, 2013 in Shanghai, China. Real-time number and mass concentrations of PM with multiple size fractions between 0.25 and 10 μm were measured. Linear mixed-effect models were used to explore the associations between size-fractionated PM concentrations and blood biomarkers at different time windows. Results Short-term exposure to PM was significantly associated with elevated levels of 5 biomarkers of inflammation, 3 biomarkers of coagulation and 1 vasoconstrictor. The effects varied considerably by particle size and time windows. Overall, PM with smaller size had stronger associations, and the most significant size fractions were 0.25–0.40 μm. Even 2 h exposure to PM can lead to a significant increase in biomarkers. The effects on biomarkers of inflammation and vasoconstriction were restricted to the first 12 h after exposure, but the effects on coagulation persisted for 24–72 h. For example, an interquartile range increase in 2 h average exposure to PM 0.25–0.40 was associated with 6–20% increase in biomarkers of inflammation, 19–38% in coagulation and 17% in vasoconstriction. PM had a stronger effect among male patients than female patients. Conclusions Our results provided important evidence on the roles of the size and time windows of exposure in the PM-mediated effects on circulating biomarkers of inflammation, coagulation and vasoconstriction in diabetes patients in China. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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